MyBioSource.com's Complement factor H antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Western Blot. The Complement factor H antibody was generated using AMBP1, ARMS1, CFH, complement factor H, Factor H, Hf, HF2, and HUS as the antigen and it reacts with Human.
Description
This gene is a member of the Regulator of Complement Activation (RCA) gene cluster and encodes a protein with twenty short concensus repeat (SCR) domains. This protein is secreted into the bloodstream and has an essential role in the regulation of complement activation, restricting this innate defense mechanism to microbial infections. Mutations in this gene have been associated with hemolytic-uremic syndrome (HUS) and chronic hypocomplementemic nephropathy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq]